Morusin attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis via dual activation of the Nrf2/HO-1 pathway and mTORC1-dependent GPX4 synthesis.

Myocardial ischemia/reperfusion injury (MIRI) involves exacerbated oxidative stress and ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation. Morusin, a flavonoid from Morus alba, exhibits antioxidant properties, but its ro…

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