Genipin rewires endogenous amino acid metabolism and induces hepatocellular necroptosis by activation of the TNF-necrosome signaling axis.

Genipin, mainly derived from the Chinese herbal medicines Gardenia jasminoides Ellis and Eucommia ulmoides Oliv., is an iridoid derivative with multiple pharmacological activities. However, genipin can exert hepatotoxicity, which limits its applicati…

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