Naunyn-Schmiedeberg's archives of pharmacology
Mechanistic insights into the antidiarrheal action of phlorizin: modulation of TLR4/NF-κB, PI3K/AKT, and HIF-1 signalling with antispasmodic and antimicrobial effects.
Ravi Kushwah, Smita Jain, Meenal Sahu, Chinchu Praisthy Lj, Siddharth Maurya, Taufik Ansari, Mansi, Ashwini Kumar Mishra, Aleksey Kuznetsov
Published: 202510.1007/s00210-025-04814-4
Abstract
This study comprehensively evaluated the antidiarrheal potential of phlorizin, a natural dihydrochalcone glycoside abundant in apple peels, using an integrated approach combining network pharmacology, molecular docking, density functional theory (DFT…
Preview only. Read the full abstract at the source