Naunyn-Schmiedeberg's archives of pharmacology
Incensole enhances anti-tumor immunity and inhibits melanoma progression by modulating macrophage polarization and suppressing metastasis.
Fatemeh Jamshidi-Adegani, Juhaina Al-Kindi, Saeid Vakilian, Fahad Al-Fahdi, Raziyeh Rezaei, Salim Al-Adawi, Nasar Alwahaibi, Asem Shalaby, Ahmed Al-Harrasi, Sulaiman Al-Hashmi
Published: 202510.1007/s00210-025-04727-2
Abstract
PURPOSE: Cutaneous melanoma, a highly aggressive skin cancer, has limited treatment options. This study explores incensole (Inc) and incensole acetate (IncA), diterpenes from Boswellia species, as immunomodulatory agents capable of reshaping the tumo…
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