Naunyn-Schmiedeberg's archives of pharmacology
Tenuigenin targets Trim31 and NF-κB pathway to protect dopaminergic neurons in Parkinson's disease mice.
Di Zhang, Chen Xu, Borui Tang, Yuyang Dai, Shaojie Guo, Zitong Fu, Zheng Fan, Xiuli Zhao
Published: 202510.1007/s00210-025-04707-6
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the SN and the accumulation of α-synuclein (α-syn). In this study, we explored the neuroprotective effects of the natural c…
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