Archives of toxicology
Pro-inflammatory response of human iPSC-derived intestinal epithelial monolayers towards microbial toxins LPS and nigericin.
Germaine Aalderink, Hugo Brouwer, Jingxuan Wang, Aafke W F Janssen, Meike van der Zande, Coen Govers, Tamara Hoppenbrouwers, Hans Bouwmeester, Mathias Busch
Published: 202510.1007/s00204-025-04215-9
Abstract
The intestinal epithelium forms a selective barrier between the intestinal lumen and the subepithelial layer. Intestinal epithelium plays a critical role in initiating inflammatory tissue responses in vivo, which remains challenging to emulate in vit…
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