Archives of toxicology
Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations.
Diletta Berardinelli, Omayema Taoussi, Duygu Yeşim Ovat, Simona Pichini, Benedikt Pulver, Volker Auwärter, Francesco Paolo Busardò, Giuseppe Basile, Emiliano Laudadio, Jeremy Carlier
Published: 202510.1007/s00204-025-04163-4
Abstract
Nitazenes have recently surfaced the illicit opioid market, causing numerous intoxications and fatalities. N-Pyrrolidino derivatives, protonitazepyne and metonitazepyne, have circulated since 2023 and have been involved in overdose intoxications. The…
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