Diabetologia
Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms.
Martina Chiriacò, Domenico Tricò, John R Petrie, Rafael Gabriel, Amalia Gastaldelli, John Nolan, Nebojsa Lalic, Geltrude Mingrone, Andrea Mari, Andrea Natali
Published: 202510.1007/s00125-025-06643-9
Abstract
AIMS/HYPOTHESIS: Fasting hyperinsulinaemia is a key feature of obesity and is implicated in diabetes progression. However, the following aspects of insulin secretion remain unclear: (1) which index of obesity is most important; (2) what is the shape…
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