Diabetologia
Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice.
Chenyang Fu, Tingting Li, Yiming Hao, Yiting Lin, Yixuan Qiu, Yangyang Jia, Jie Yang, Bei Liu, Duanyi Hua, Chengyang Wang, Tao Chen, Anthony Piron, Miriam Cnop, Qicheng Ni, Jie Zheng
Published: 202510.1007/s00125-025-06618-w
Abstract
AIMS/HYPOTHESIS: Diet switch during weaning induces gut microbiome maturation, accompanied by the formation of adequate functional beta cell mass. Bile acid (BA), an essential microbial metabolite, regulates host glucose homeostasis by binding to its…
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