Journal of molecular medicine (Berlin, Germany)PodocytesOxidative StressAnimalsRNA-Binding ProteinsMice
GATA1 controls metadherin transcription to promote oxidative stress-induced podocyte injury.
Yihua Chen, Wenting Wu, Liyuan Zhao, Lingyu Shen, Danping Tao, Yunyi Liang, Xiaohong Zheng, Zerong Zheng, Congwei Luo, Fenfen Peng, Haibo Long, Xiaowen Chen
Published: 202510.1007/s00109-025-02633-x
Abstract
Oxidative stress has been demonstrated to induce damage to podocytes, which play a pivotal role in the pathogenesis of chronic kidney disease (CKD). Metadherin (MTDH), an oncogene that has been extensively investigated in various malignancies, also c…
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