Journal of molecular medicine (Berlin, Germany)HumansSignal TransductionNucleotidyltransferasesLiver CirrhosisMembrane Proteins
cGAS-STING signaling pathway in MASLD and liver fibrosis.
Yang Xiao, Yufang Ma, Can Gan, Zhiyin Huang, Jinhang Gao
Published: 202610.1007/s00109-025-02612-2
Abstract
In metabolic dysfunction-associated steatotic liver disease (MASLD), lipid accumulation and inflammatory stimulation lead to the release of damage-associated molecular patterns, thereby inducing the activation of the cyclic GMP-AMP synthase (cGAS)-st…
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