Journal of molecular medicine (Berlin, Germany)AnimalsMyocytesCardiacMyocardial Reperfusion InjuryAutophagy
Suppression of OTUD4 protects against myocardial ischemia-reperfusion injury by increasing autophagic flux and inhibiting apoptosis in cardiomyocytes.
Xin-Xin Sun, Lin Qi, Ming-Jun Dai, Fang-Lin Lu, Yi-Min Xiao, Wei-Jin Sun, Yu Zhuang
Published: 202510.1007/s00109-025-02605-1
Abstract
Dysregulated autophagic flux plays a critical role in myocardial ischemia-reperfusion injury (MIRI), complicating cardiac reperfusion therapy. In this study, we identified OTUD4 as a potential regulator of autophagic flux in MIRI using CRISPR/Cas9 sg…
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