Cellular and molecular life sciences : CMLS
Cathelicidin-Ka, the first frog-derived TLR2 and TLR4 agonist, induces macrophage activation and promotes inflammation.
Jinwei Chai, Jiena Wu, Shuiying Zhang, Wenjun Zhang, Weichen Xiong, Jinqiao Li, Tienthanh Nguyen, Lixia Shu, Michail Kotsyfakis, Xin Chen, Xueqing Xu
Published: 202610.1007/s00018-025-06068-y
Abstract
TLR-targeted immunotherapy represents a promising strategy for combating infectious diseases by initiating or enhancing protective antimicrobial immunity. Here, we identified the first frog-derived TLR2 and TLR4 agonist, Cathelicidin-Ka (Cath-Ka), fr…
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