Cellular and molecular life sciences : CMLS
A decoy oligodeoxynucleotide favors the differentiation of CpG ODN-induced B cells into IL-10-producing Breg-like cells over plasma cells by restoring IRF4/IRF8 imbalance.
Feiyu Lu, Shengnan Wang, Mengru Zhu, Kuo Qu, Tong Zhu, Hong Wang, Yongli Yu, Liying Wang
Published: 202610.1007/s00018-025-06033-9
Abstract
The imbalanced expression of interferon regulatory factor (IRF) 4 and IRF8 in activated B cells significantly influences their differentiation and promotes the development of immune-related diseases. Restoring abnormal B cells to appropriate response…
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