Inflammation research : official journal of the European Histamine Research Society ... [et al.]AnimalsPsoriasisHumansProto-Oncogene Proteins c-aktPhosphatidylinositol 3-Kinases
Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K/AKT signaling pathway.
Xiaoke Liu, Simo Du, Yuxiong Jiang, Youdong Chen
Published: 202510.1007/s00011-025-02111-7
Abstract
OBJECTIVE AND DESIGN: This study was designed to delineate how Piezo1 orchestrates macrophage polarization and autophagy in psoriasis and to determine whether the PI3K/AKT axis mediates these effects. MATERIAL OR SUBJECTS: Wild-type and Piezo1-knocko…
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