Advances in experimental medicine and biologyHumansAcidosisDual Specificity Phosphatase 6MAP Kinase Signaling SystemGene Expression Regulation
Role of the Dual-Specificity Phosphatase 6 (DUSP6) in the Activation of ERK1/2 Signaling by Hypoxia or Acidosis in Tumor Cells.
Anne Riemann, Sarah Reime, Oliver Thews
Published: 202610.1007/978-3-032-10389-5_13
Abstract
Important pathophysiological characteristics of human tumors are the presence of hypoxia and of an extracellular acidosis. Both metabolic parameters can affect the malignant behavior of tumors but also the response to treatments. Here the modulation…
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