Advances in experimental medicine and biologyMicrogliaTRPM Cation ChannelsAnimalsCopperProtein Kinase C
Copper-Induced Microglial Activation Involves PKC/NOX/PARP-1/TRPM2 Signaling Pathway.
Tze Wei Chew, Nur Zulaikha Mohamad Zahir, Amir Syahir Amir Hamzah, Sharifah Alawieyah Syed Mortadza
Published: 202610.1007/978-3-032-03398-7_32
Abstract
Copper (Cu2+) is vital for proper brain function, serving as a cofactor in essential biological processes. However, excessive levels of Cu2+ can disrupt redox homeostasis, resulting in oxidative stress. TRPM2 channel is a Ca2+-permeable channel that…
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