Methods in molecular biology (Clifton, N.J.)AnimalsHypoxanthine PhosphoribosyltransferaseRatsMutationMembrane Proteins
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes.
Vasily N Dobrovolsky, Joseph G Shaddock, Roberta A Mittelstaedt, Daishiro Miura, Robert H Heflich
Published: 202610.1007/978-1-0716-4976-3_5
Abstract
Assays for in vivo mutation are used to identify genotoxic hazards and phenotypes prone to genomic instability and cancer. The hypoxanthine guanine phosphoribosyl transferase (Hprt) gene and the phosphatidyl inositol glycan, class A, (Pig-a) gene are…
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