Handbook of experimental pharmacologySignal TransductionReceptorsG-Protein-CoupledHumansAnimals
S-Nitrosylation of GPCR Regulatory Machinery as a Mechanism to Bias Signaling.
Mingda Chen, Zachary W Grimmett, Richard T Premont, Jonathan S Stamler
Published: 202610.1007/164_2025_765
Abstract
Upon stimulation by endogenous ligands, G protein-coupled receptors (GPCRs) activate downstream signaling pathways through multiple mechanisms, including G protein subtypes, β-arrestins, and receptor-specific partners. Synthetic ligands may activate…
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