A Roadmap for Advancing Women's Health in Disorders of the Gut-Brain Interaction.

Disorders of the Gut-Brain Interaction (DGBI) are highly prevalent conditions that all gastroenterologists encounter in clinical practice. Differences between men and women in the prevalence and symptom burden of DGBI have been well documented in numerous epidemiological and observational studies. Few have identified how DGBI are affected by hormonal changes in women through the lifespan or comorbid conditions and ultimately if and how treatment pathways should differ. This review aims to synthesize current evidence on women's health in the context of DGBI and suggest future directions for clinical studies and trials. Improving women's health in DGBI will require clinical trials that intentionally account for hormonal influences on symptoms and treatment outcomes, inclusion of sex-specific comorbidities, and collaborative, cross-disciplinary trial designs that address overlapping symptoms.