Small methodsDoxorubicinHumansElectron TransportAnimalsCytochrome P-450 Enzyme System
Unveiling a Doxorubicin-Cytochrome P450 Electron Transfer Pathway for Synergistic Multimodal Tumor Therapy.
Wenbo Yin, Zonghang Liu, Shangjie An, Tao Song, Yue Wang, Xiue Jiang
Published: 202510.1002/smtd.202501358
Abstract
Doxorubicin (DOX) is a clinically approved chemotherapeutic agent that exerts its cytotoxicity through DNA intercalation and topoisomerase II inhibition. However, its redox-based mechanism remains underexplored. Here, it is revealed that DOX specific…
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