Small (Weinheim an der Bergstrasse, Germany)NanoparticlesTumor MicroenvironmentDoxorubicinAnimalsHumans
Autonomous Braking of Host-Guest Nanoparticles for Enhanced Tumor Tissue Penetration and Retention.
Yangyang Xiang, Feichi Wang, HongYuan Hao, Hong Wang, Junyi Xue, Guang Jia, Jin Liu, Zhenhua Li, Xing-Jie Liang, Jinchao Zhang, Dandan Liu
Published: 202610.1002/smll.202509060
Abstract
The tumor microenvironment (TME), characterized by high interstitial pressure, acidic pH, and dense extracellular matrix, poses significant barriers to efficient drug delivery, limiting the therapeutic efficacy of conventional nanomedicines. Although…
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