Rapid communications in mass spectrometry : RCMDrug ContaminationPeptidesChromatographyLiquidTandem Mass Spectrometry
Identification and Quantification of Structurally Related Peptide Impurity in Linaclotide by Liquid Chromatography-High Resolution Mass Spectrometry.
Jinlan Cheng, Tianji Zhang, Xinling Cui, Peize Wu, Ming Li, Wenrui Hu, Xueting Dai, Xuesong Feng
Published: 202610.1002/rcm.70030
Abstract
RATIONALE: Linaclotide is an important peptide drug used to treat irritable bowel syndrome with constipation (IBS-C). However, structurally related impurities in peptide drugs can be generated during synthesis, storage, or transport, which compromise…
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