Rapid communications in mass spectrometry : RCMAnimalsMicrosomesLiverTandem Mass SpectrometryRats
Metabolic Profiling of Sitravatinib in Rat and Human Liver Microsomes Using LC-MS/MS and LC-Orbitrap-HRMS.
Shan Xu, Ying Zhu, Wenxia Liu, Guanging Bao, Linfei Li
Published: 202610.1002/rcm.70001
Abstract
RATIONALE: Sitravatinib is a receptor tyrosine kinase inhibitor that has been developed for the treatment of advanced nonsmall-cell lung cancer (NSCLC) and urothelial carcinoma. This study aimed at developing an integrated LC-MS/MS and LC-Orbitrap-HR…
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