Phytotherapy research : PTR
A Novel Mechanism of Berberine Targeting EIF2AK2 Dimerization Attenuates Methylglyoxal-Induced Endothelial Senescence and Apoptosis.
Jinxiang Chen, Yumeng Yang, Haiyang Li, Junjing Xiong, Liqun Wang, Chunxiang Zhang, Mao Luo
Published: 202610.1002/ptr.70203
Abstract
Vascular aging, a central feature of organismal aging, involves endothelial cell (EC) structural and functional alterations. Methylglyoxal (MGO), a key advanced glycation end product precursor, pathologically accumulates during aging. While MGO induc…
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