Phytotherapy research : PTRAnimalsNitric Oxide Synthase Type ISerotoninMiceMale
Plumbagin Alleviates Mild Traumatic Brain Injury-Induced Obsessive-Compulsive Disorder in Mice by Inhibiting nNOS and Augmenting Cortico-Striatal Serotonin Levels.
Kamini R Shirasath, Akshay K Chaudhari, Kartik T Nakhate, Sameer N Goyal, Sanjay N Awathale
Published: 202510.1002/ptr.70105
Abstract
Increased nitric oxide activity in the medial prefrontal cortex (mPFC) and striatum plays a key role in the pathogenesis of obsessive-compulsive disorder (OCD) by lowering serotonin contents and triggering neurodegeneration. Since molecular docking a…
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