CPT: pharmacometrics & systems pharmacologyHumansMaleFemaleEosinophilic EsophagitisMiddle Aged
Latent Variable Indirect Response Modeling of Cendakimab Exposure-Response for Longitudinal Dysphagia Days Using a Combined Uniform-Binomial Likelihood Framework.
Shengnan Du, Jessica Wojciechowski, Peijin Zhang, Urvi Aras, Bindu Murthy, Jun Shen, Anna Kondic, Chuanpu Hu
Published: 202610.1002/psp4.70199
Abstract
To characterize the relationship between cendakimab exposure and the longitudinal efficacy endpoint dysphagia days (DD), E-R analyses were performed using data from the EE-001 study (N = 427) with eosinophilic esophagitis. DD-a bounded, discrete endp…
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