Pharmacotherapy
Effect of Testosterone Therapy on Cytochrome P450 3A and P-Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults.
Michiko Hunter, Rene Coig, Linda Risler, Kristen K Patton, Radhika R Narla, Dina N Greene, Alson K Burke, Elizabeth Micks, Mary F Hebert, Lauren R Cirrincione
Published: 202510.1002/phar.70093
Abstract
BACKGROUND: Gender-affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug-metabolizing enzymes and transporters, bu…
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