The Journal of pathology
Relative MYC downregulation and RUNX2 upregulation orchestrate partial epithelial-mesenchymal transition in colorectal cancer tumor budding and poorly differentiated clusters.
Tsuyuha Koba, Takashi Hibiya, Takahiro Shibayama, Kenichiro Kato, Hiromi Onizuka, Kashi Satomi, Kiyotaka Nagahama, Eiji Sunami, Nobutsugu Abe, Eiryo Kawakami, Junji Shibahara, Akimasa Hayashi
Published: 202610.1002/path.70013
Abstract
Tumor budding and poorly differentiated clusters are key prognostic indicators in colorectal cancer, yet the molecular mechanisms underlying their formation remain incompletely characterized. Using the GeoMx Digital Spatial Profiler, we analyzed gene…
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