The Journal of pathology
Mining bulk transcriptomic datasets identifies inflammasome activation and antigen presentation as key novel mechanisms of BK polyomavirus-associated nephropathy.
Lachlan A Davidson, Natalie M Niessen, Matthew Rowlandson, Adrian D Hibberd, Munish K Heer, Alan Cy Hsu, Gerard E Kaiko, Andrew T Reid, Jemma R Mayall, Jay C Horvat, Paul R Trevillian, Katherine J Baines
Published: 202610.1002/path.70012
Abstract
BK polyomavirus (BKPyV) is a viral infection experienced by kidney transplant recipients that can lead to the development of BKPyV-associated nephropathy (BKPyVAN), graft dysfunction, and loss. There are no BKPyV-specific treatments available to prev…
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