ChemistryOpen
Synthesis of Pyrido[2,3-d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor-Targeted Molecular Docking Toward Novel Anticancer Leads.
Sobhi M Gomha, Sami A Al-Hussain, Basant Farag, AbdElAziz A Nayl, Wesam Hussein, Abdelwahed R Sayed, Magdi E A Zaki
Published: 202510.1002/open.202500555
Abstract
A new class of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidinones and pyrido[2,3-d]thiazolo[3,2-a]pyrimidinones was synthesized by reacting 5-phenyl-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one with hydrazonoyl halides and α-bromoketones via a…
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