ChemistryOpen
Disarming the Hsp70-Bim Alliance: Small-Molecule and Peptidic Disruptors of a Chaperone-Apoptotic Switch in Cancer.
Emadeldin M Kamel, Mohammed Al-Zharani, Lina M Alneghery, Noha A Ahmed, Faris F Aba Alkhayl, Al Mokhtar Lamsabhi
Published: 202510.1002/open.202500479
Abstract
Heat-shock protein 70 (Hsp70) is a ubiquitous stress chaperone whose over-expression confers treatment resistance in many cancers. Recent structural and mechanistic work has uncovered an unexpected survival circuit: the proapoptotic BH3-only protein…
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