Obesity (Silver Spring, Md.)AnimalsWeight LossDependovirusMiceAgouti-Related Protein
Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches.
Hunter G Sellers, Zachary L Brown, Noureen S Khalil, Stephen B Haigh, Mitchell A Shivers, Tej V Patel, Austin T Joshua, Neal L Weintraub, Scott A Barman, Eric J Belin de Chantemele, Sergei A Kirov, David W Stepp, David J R Fulton
Published: 202610.1002/oby.70081
Abstract
OBJECTIVE: This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic…
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