Muscle & nerve
Elevated Serum SIRT2 Is Associated With Rapid Progression and Cognitive Impairment in Amyotrophic Lateral Sclerosis.
Jun Zhu, Tianrui Wen, Ninglu Gao, Mingjie Ma, Xiaohan Sun, Fuchen Liu, Pengfei Lin, Shuangwu Liu
Published: 202610.1002/mus.70162
Abstract
INTRODUCTION/AIMS: Amyotrophic lateral sclerosis (ALS) lacks reliable biomarkers to predict disease trajectories or guide therapeutic strategies. Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase implicated in cytoskeletal destabilization and neuroinfl…
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