Movement disorders : official journal of the Movement Disorder Society
Feasibility of Simon Two-Stage Futility Trials in People with Early, Symptomatically Treated Parkinson's Disease.
Marcus W Koch, Lorraine V Kalia, Justyna Sarna, Camila Aquino, Daryl Wile, Tiago A Mestre, Michael G Schlossmacher, Miguel D'Haeseleer, Jop Mostert, Eva M M Strijbis, Bernard Uitdehaag, Tarrant McPherson, Gary Cutter
Published: 202510.1002/mds.70090
Abstract
BACKGROUND: Disease-modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two-stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. OBJECTIVE…
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