Movement disorders : official journal of the Movement Disorder Society
Depression in Premanifest Huntington's Disease: Aberrant Effective Connectivity of Striatum and Default Mode Network.
Tamrin Barta, Leonardo Novelli, Nellie Georgiou-Karistianis, Julie Stout, Samantha M Loi, Yifat Glikmann-Johnston, Adeel Razi
Published: 202510.1002/mds.70075
Abstract
BACKGROUND: Depression frequently precedes motor symptoms in Huntington's disease gene expansion carriers (HDGECs), yet the neural mechanisms remain poorly characterized. OBJECTIVE: We investigated effective connectivity between the default mode netw…
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