Molecular carcinogenesisHumansCarcinomaHepatocellularLiver NeoplasmsAnimals
TOP2A, Stabilized by IGF2BP3 in an m6A-Dependent Manner, Drives Macrophage Recruitment and M2 Polarization in Hepatocellular Carcinoma by YAP1-Mediated CCL2 Activation.
Lu Li, Chenxu Du, Nai Sun, Xingguo Xiao, Kunkun Li, Huili Wu, Jianzhuang Gong
Published: 202610.1002/mc.70059
Abstract
M2-like tumor-associated macrophages (TAMs) exert immunosuppressive and protumorigenic functions in hepatocellular carcinoma (HCC). In this study, we explored the function and mechanism of Type IIA topoisomerase (TOP2A) in TAM recruitment and M2 pola…
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