Molecular carcinogenesisHumansMelanomaGlycolysisThyroid Hormone-Binding ProteinsThyroid Hormones
POU4F1 Promotes the Primary Resistance of Melanoma to Anti-PD-1 Therapy by Regulating Glycolysis Through METTL1-Mediated m7G Methylation of PKM2.
Lin Liu, Xiaokang Li, Xinhong Hu, Da Zhai, Tianyu Cao, Ling Liu
Published: 202510.1002/mc.70049
Abstract
Melanoma, a highly malignant tumor originating from melanocytes, has seen a significant increase in global incidence, particularly among the elderly. Anti-PD-1 monoclonal antibodies, which activate the immune system to attack cancer cells by blocking…
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