Macromolecular bioscienceChitosanAnimalsInsulinPolysaccharidesNanoparticles
Insulin-Loaded Muco-Inert Nanoparticles Based on L-valine-modified Chitosan and Fucoidan for Enhanced Oral Delivery.
Changsheng Gan, Huiya Li, Liu Yang, Tianling Zhang, Kun Xu, Honglei Wang, Shiji Sun, Chuanxun Yuan, Ailing Hui, Wencheng Zhang
Published: 202610.1002/mabi.202500586
Abstract
Oral delivery of insulin faces significant challenges due to various barriers present in the gastrointestinal tract, leading to minimal therapeutic outcomes. To overcome these obstacles, chitosan-based nanoparticles modified by L-valine were designed…
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