Macromolecular bioscience
A Double-Layer Microneedle Patch Containing Methylprednisolone and Upadacitinib-Loaded Mesoporous Silica Nanocomposites for Psoriasis Treatment.
Die Li, Ting Wang, Yi Liu, Haojie Bi, Xuan Xu, Hanying Wang, Qianwei Jin, Shaochun Chen, Lechun Lyu, Jingpei Shi
Published: 202510.1002/mabi.202500530
Abstract
Psoriasis is promoted by signaling through the IL-23/IL-17 pathway. Existing oral or topical treatment regimens can hardly balance acute flare-ups with long-term maintenance. A dual-layer soluble microneedle (MN) that combines methylprednisolone (MP)…
Preview only. Read the full abstract at the source