Rates of parent-reported allergic conditions in children at-risk of celiac disease.

Allergies and other chronic immune mediated conditions are becoming increasingly common. Here we utilized a prospective birth cohort called the Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) study to examine the frequency of parent reported allergic conditions and their association with celiac disease (CeD). We examined 271 children at-risk of CeD from the United States and found a high frequency of allergic conditions. In our overall cohort, 19.8% reported food protein-induced allergic proctocolitis (FPIAP), 12.5% reported IgE-mediated food allergy, and 14.7% reported atopic dermatitis. Among the 23 children with CeD, 21.74% had FPIAP, 8.7% had an IgE-mediated food allergy, and 21.74% had atopic dermatitis. No significant association between allergic conditions and CeD was found (p > 0.35 for all). These results highlight the widespread occurrence of parent-reported allergic conditions in children but do not suggest an association between allergic conditions and CeD development.