Synthesis and Characterization of 2-Thiophenemethanamine-2H5 Hydrochloride.

Synthesis of the key building block, 2-thiophenemethanamine-2H5 hydrochloride, was achieved using mild conditions and purification methods in three steps from commercially available thiophene-2H4, with an overall yield of 61.6% and an overall isotopic enrichment of 87.6%. 2-thiophenemethanamine-2H5 hydrochloride has the potential to be a useful intermediate in the synthesis of isotopically labelled compounds of pharmaceutical interest.