Journal of inherited metabolic diseaseHumansLipid MetabolismVascular CalcificationDiphosphatesPhosphoric Diester Hydrolases
Lipid Metabolism Alterations in Hereditary Inorganic Pyrophosphate Deficiency Syndromes: A Narrative Review of Insights and Controversies.
Robbe Derudder, Olivier M Vanakker
Published: 202610.1002/jimd.70129
Abstract
Pathological ectopic calcification of soft tissues can arise from reduced or absent levels of inorganic pyrophosphate (PPi), a key inhibitor of calcium hydroxyapatite deposition in soft connective tissues. The role of PPi in regulating mineralization…
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