The journal of gene medicineHumansColorectal NeoplasmsCell ProliferationHistone DemethylasesCell Line
KDM1A Facilitates Oncogenic Potential in Colorectal Cancer Progression Through the Activation of AXIN/GSK3β/β-Catenin Signaling Pathways: Evidence From Integrated Transcriptomics and In Vitro Studies.
Sathan Raj Natarajan, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Mansour K Gatasheh, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Chella Perumal Palanisamy, Selvaraj Jayaraman
Published: 202510.1002/jgm.70053
Abstract
BACKGROUND: Colorectal cancer (CRC) is a major cause of cancer-related death and is driven by epigenetic alterations. KDM1A, a key histone demethylase, has a poorly defined role in CRC. This study investigates its molecular mechanisms using bioinform…
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