The Prevalence of Esophageal Hypomotility and Its Relationship With Dysmotility Score in Vietnamese Patients Having Reflux Symptoms.

Aim: This study aimed to determine the prevalence of esophageal hypomotility and examine its association with FSSG scores among Vietnamese patients presenting with reflux symptoms. Methods: A cross-sectional study was conducted in 403 adults with reflux-suspected symptoms and a GERD-Q score ≥ 8 undergoing high-resolution manometry (HRM) at Hoang Long Clinic (Hanoi, Vietnam). FSSG comprised two main components, including reflux score (FSSG-R) and dysmotility score (FSSG-M). Esophageal motility disorders were classified according to Chicago Classification v4.0; hypomotility disorders included ineffective esophageal motility (IEM) and absent contractility. Results: The mean FSSG total score and FSSG-M score were 15.91 ± 5.94 and 8.03 ± 3.84, respectively. On manometry, 66.0% of patients had a diagnosis of esophageal hypomotility, predominantly IEM (63.5%). Esophagogastric junction (EGJ) hypotension and EGJ morphology type III were seen in 15.38% and 3.47%, respectively. There were no significant differences on FSSG scores between patients with normal esophageal motility and hypomotility. Linear regression analysis showed no correlation between the FSSG-M score and distal contractile integral (DCI) or the number of ineffective swallows. In the multivariable logistic regression model, female and EGJ hypotension were significantly associated with the presence of esophageal hypomotility (aOR = 1.582 and 4.094, respectively). Conclusions: The prevalence of esophageal hypomotility among Vietnamese patients having reflux symptoms was high. FSSG total score and its dysmotility component score were not associated with the presence of esophageal hypomotility.