International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceAnimalsValproic AcidMiceFemaleBrain
Valproic Acid Exposure During the Brain Growth Spurt Leads to Autistic-Like Behaviours in Mice.
Bruna Lotufo-Denucci, Monica Cena de Sousa, Nathan Alesi de Paula Aguiar, Danielle Paes-Branco, Vitor Hugo Santos Duarte Pinheiro, Ulisses César Araújo, Fernanda Uchoa Braga, Carolina Azevedo de Souza, Anderson Ribeiro-Carvalho, Yael Abreu-Villaça, Alex C Manhães, Cláudio C Filgueiras
Published: 202510.1002/jdn.70056
Abstract
Prenatal exposure to valproic acid (VPA) has been associated with an increased risk of autism spectrum disorder (ASD). Studies in rodents have demonstrated that VPA exposure during the first trimester-equivalent period of gestation results in a lifel…
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