Journal of clinical pharmacologyHumansAntihypertensive AgentsLiver CirrhosisModelsBiological
Using Physiologically Based Pharmacokinetic Modeling and Simulations to Predict Antihypertensive Drug Doses in Cirrhotic Patients.
Mai Tarek, Ahmed A Ali, Reda Biomy, Khaled Abdelkawy, Eman El-Khateeb
Published: 202610.1002/jcph.70148
Abstract
Liver cirrhosis can alter drug pharmacokinetics, often requiring dose adjustments. Physiologically based pharmacokinetic (PBPK) modeling aids in predicting these pharmacokinetic changes in cirrhosis patients. This study developed and validated PBPK m…
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