Journal of cellular physiologyHumansCell DifferentiationEndoglinWnt Signaling PathwayHuman Embryonic Stem Cells
Endoglin Regulates Pluripotency and Differentiation in Human Embryonic Stem Cells Through Wnt and TGF-β Signaling Crosstalk.
Min-Tae Kim, Minje Kang, Suji Jeong, Hyebin Koh, Xing Zhen, Seung-Joon Lee, Do-Yeon Kim, Seok-Ho Hong, Jong-Hee Lee
Published: 202610.1002/jcp.70135
Abstract
Although endoglin (ENG) is traditionally recognized as a coreceptor in TGF-β signaling, its role in human pluripotent stem cells (hPSCs) remains unexplored. Here, we report that ENG knockout (ENG-/-) hPSCs maintain core pluripotency markers yet under…
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