Journal of cellular biochemistryHumansMultiple MyelomaReceptorsCXCR4STAT3 Transcription Factor
Extracellular Ubiquitin Drives M2 Macrophage Polarization in Multiple Myeloma Through JAK1/STAT3-mediated Transcriptional Activation of CXCR4.
Xi Chen, Nan Hou, Tiancheng Luo, Xinyi Zhou, Dongjian Chen, Wanting Qiang, Jin Liu, Pei Guo, Jing Lu, Juan Du, Haiyan He
Published: 202510.1002/jcb.70073
Abstract
Macrophage polarization engenders an immunosuppressive microenvironment, thereby facilitating the survival and epithelial-mesenchymal transition (EMT)-like changes of malignant plasma cells. Ubiquitin (Ub), a short polypeptide predominantly involved…
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