Journal of biochemical and molecular toxicologyAnimalsNF-E2-Related Factor 2NLR FamilyPyrin Domain-Containing 3 ProteinOxidative Stress
Isoliquiritigenin, Nrf2 Activator, and NLRP3 Inhibitor Protects Isoniazid-Induced Hepatotoxicity in Sprague-Dawley Rats: Studies on Oxidative Stress, Inflammation, DNA Damage, Ferroptosis, and Steatosis.
Gurpreet Singh, Mohammad Aabis, Vaishali Maurya, Vinod Kumar, Gopabandhu Jena
Published: 202610.1002/jbt.70717
Abstract
Isoniazid (INH), a widely used first-line anti-tubercular drug, has significant concern for the hepatotoxicity in humans induced by oxidative stress, inflammation and steatosis. INH activates NLRP3 inflammasome and inhibits Nrf2 activation pathways.…
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